Week 1’s barrage of games over a five-day period is here! Here’s the new “Weekly Picks” segment featuring picks against the spread for all games featuring Top 25 teams.

[Editor’s Note: All odds courtesy of OddsShark.com. As of Thursday, there were no lines for games of #18 Miami, #19 USF, and #20 Kansas State, as all are playing FCS schools]

• #3 Florida State vs. #1 Alabama (-6.5)

This is Alabama’s sixth straight year facing another Power 5 school in the season opener. The Tide’s average margin of victory in the previous five? 25.2. Lay the points and roll with the Tide.

— Pick: Alabama

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• #2 Ohio State at Indiana (+20)

Indiana has played Top 25 teams close in Bloomington in recent years, including a 31-24 loss to the Buckeyes in 2015 that came down to the final play. The Hoosiers will be competitive enough to cover.

— Pick: Indiana

 • Western Michigan at #4 USC (-22)

Western Michigan is coming off a trip to the Cotton Bowl but head coach P.J. Fleck, QB Zach Terrell and WR Corey Davis are all gone. The Trojans will roll WMU in the Coliseum.

— Pick: USC

• Kent State at #5 Clemson (-40)

The defending national champions face a team coming off a 3-9 season whose head coach, Paul Haynes, just took a medical leave of absence. Clemson will win YUGE.

— Pick: Clemson

• Akron at #6 Penn State (-35)

Last year, Akron’s nonconference game vs. a Big Ten team resulted in a 54-10 loss to Wisconsin. This will be just as ugly.

— Pick: Penn State

 • UTEP at #7 Oklahoma (-48)

New Sooners head coach Lincoln Riley wants to prove OU won’t miss a beat without Bob Stoops and Heisman hopeful QB Baker Mayfield will be thrilled to pad his stats.

— Pick: Oklahoma

• Utah State at #9 Wisconsin (-34)

Once a solid Group of 5 program, Utah State is headed in the wrong direction after a 3-9 season in 2016. The 2017 season will start on a similar note.

— Pick: Wisconsin

• Tulsa at #10 Oklahoma State (-17)

Tulsa still hasn’t named a starting quarterback while Oklahoma State has the most powerful offense in the Big 12. The Cowboys will rip right through the Golden Hurricane.

— Pick: Oklahoma State

• #17 Florida vs. #11 Michigan (-3)

Florida is now up to 10 players suspended for the opener, with more suspensions possibly on the way. That’s too much chaos to win a season opener like this.

— Pick: Michigan

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• Georgia Southern at #12 Auburn (-36)

Georgia Southern returns 17 starters and should hang around a while, like the Eagles did in a 10-point loss at Ole Miss last season.

— Pick: Georgia Southern

• BYU vs. #13 LSU (-12.5)

BYU was hardly impressive in its season-opening 20-6 win over FCS Portland State. Throw in the game being moved from Houston to New Orleans due to Hurricane Harvey and this will be a rout.

— Pick: LSU

• Appalachian State at #15 Georgia (-14)

A decade ago, Appalachian State shocked the college football world by knocking off Michigan in Ann Arbor. The Mountaineers are coming off a 10-3 season and could pull off another shocker.

— Pick: Appalachian State

• #16 Louisville vs. Purdue (+23.5)

Louisville ended the 2016 season with three straight losses to Houston, Kentucky and LSU. Purdue has enough optimism under new head coach Jeff Brohm to keep it within 3 touchdowns.

— Pick: Purdue

 • #22 West Virginia vs. #21 Virginia Tech (+2.5)

Virginia Tech is breaking in a freshman QB in Josh Jackson while West Virginia is handing the reigns to Florida transfer Will Grier, who has drawn rave reviews in Morgantown. Take the experience in a shootout.

— Pick: West Virginia

• Maryland at #23 Texas (-17.5)

It’s so hard to tell how a team will play in its first game under a new head coach and The Eyes of Texas are all on Tom Herman. The Longhorns will start slow but pull away late.

— Pick: Maryland

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About Jim Weber

Jim Weber is the founder of College Sports Only. He has worked at CBS Sports, NBC Sports and ESPN the Magazine and is the founder of a previous college sports website, Lost Lettermen (R.I.P.).

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